Nicotinamide Riboside: Side effects and testings

Nicotinamide riboside chloride is considered as the upgraded version of pyridine-nucleoside and considered as the precursor of nicotinamide adenine dinucleotide or NAD+. The molecular weight of this compound is 255.25 g/mol in which the molecular weight of chloride salt is 290.70 g/mol. According to a research 100 mg quantity of nicotinamide riboside, provide you near about 88 mg of nicotinamide riboside.


However, it is a part of vitamin B3 so it has its own unique properties and because of these properties, you can easily distinguish it with B3 vitamin-like niacin and nicotinamide. A study that is conducted on mice clearly shows that the effect of all the compounds tends to be the same and they all showed equal effects on NAD+ metabolome. Some of the different biosynthetic pathways resulted to help in the process of converting B3 vitamin into NAD+.

According to some studies that are conducted on animals clearly shows that the reaction of these compound becomes different depending on the age and stress. A model that is created on dilated cardiomyopathy is clearly stated that NRK2 mRNA is inversely proportional to Nampt mRNA expression. Is a similar case it is observed that there is an increment in NRK1 and NRK2 could be observed in the peripheral neurons and injured central?


Some of the impacts shown by Niacin are it will cause you skin flushing and the reason behind this flushing is the activation of GPR109A G-protein. There is no role of NR in activating this receptor and it also not cause you any kind of skin flushing until you take it more than its intake capacity which is 2000 mg/ day.

Nicotinamide works as an inhibitor of NAD+- in place of working as a precursor. It consumes sirtuin and just because of it, they are able to create O-acetyl-ADP-ribose and nicotinamide. The product from this reaction tends to be as deacetylation. If the person takes it in a heavy dose then it will increase the hepatic levels of O-acetyl-ADP-ribose.


In a research conducted in 2004, it is clearly mentioned that NR can be converted into NAD+ with the help of eukaryotic nicotinamide riboside kinase pathway process. Along with it, he also suggested his patients about its uses in 2006. The commercial use of this medicine got started in 2012 and with the help of this medicine, NR gets into the market.

ChromaDex got the patent over the Elysium Health and got the rights for nicotinamide riboside supplements. Many researches are conducted on both men and women. One test is done for the combination of NR with pterostilbene and the other four are conducted for the side effects of NR individually.

Nicotinamide Riboside: Side effects and testings


With the final words, we conclude that in this article we have mentioned Nicotinamide riboside and some of the positive the same like Oleoylethanolamide (OEA) at  and negative impacts that it will cause to the human body. Moreover, we have also mentioned some of the information is that you cannot find on any of the platforms. So follow them and be safe.